![]() For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Research articles, review articles as well as short communications are invited. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. All submissions that pass pre-check are peer-reviewed. Manuscripts can be submitted until the deadline. Once you are registered, click here to go to the submission form. Manuscripts should be submitted online at by registering and logging in to this website. This Special Issue of Antibodies focuses on recent advances in antibody repertoire mining from human and other organisms, including, high-throughput single B cell technologies for antibody discovery, NGS data mining pipeline and in silico analysis for clone selection and improved antibody library generation, evolutionary and developmental aspects of B-cell receptor repertoires, maturation pathway analysis for vaccine design, and understanding immunogenetic and molecular basis of antibody responses at the repertoire level to pathogens, vaccines and autoantigens. Exploring genetic diversity of these repertoires and their impacts on the humoral immune response is the subject of active investigations that have tremendous applications, such as antibody discovery, immune profiling in disease conditions (ex., autoimmunity, cancer and viral infection) and following vaccination, and B-cell lineage-based approach to vaccine design. Recently, comparative deep sequencing studies of antibody repertoires between individuals have revealed the existence of public and private repertoires. However, detailed analyses of antibody repertories in different stages of ontogeny, development, immunological condition and responses have demonstrated that normal and immune repertoires can be constrained and shaped by natural selection, immune checkpoints, and exposure to autoantigens, microbes and vaccines. Immunogenetic mechanisms underlying the complex processes of antibody V(D)J gene rearrangement, junctional modification, and somatic mutation, which appear to randomly create repertoires of vast diversity.
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